St. Matthews is a town in Calhoun County, South Carolina, United States. The population was 2,021 at the 2010 census, a decline from 2,107 in 2000. It is the county seat of Calhoun County. St. Matthews is part of the Columbia, South Carolina Metropolitan Statistical Area.
St. Matthews is located in the center of Calhoun County at 33°39′53″N 80°46′44″W (33.664734, -80.778976). U.S. Route 601 passes through the town, leading northeast 51 miles (82 km) to Camden and southwest 13 miles (21 km) to Orangeburg. South Carolina Highway 6 crosses US 601 in the center of town and leads west 7 miles (11 km) to Interstate 26 and southeast 22 miles (35 km) to Interstate 95 near Santee. According to the United States Census Bureau, St. Matthews has a total area of 1.93 square miles (4.99 km²), of which 1.92 square miles (4.97 km²) is land and 0.01 square miles (0.02 km²), or 0.35%, is water.
As of the census of 2000, there were 2,107 people, 823 households, and 549 families residing in the town. The population density was 1,091.1 people per square mile (421.5/km²). There were 913 housing units at an average density of 472.8 per square mile (182.6/km²). The racial makeup of the town was 37.16% White, 61.46% African American, 0.05% Native American, 0.09% Asian, 0.14% Pacific Islander, 0.38% from other races, and 0.71% from two or more races. Hispanic or Latino of any race were 1.33% of the population.
There were 823 households out of which 27.2% had children under the age of 18 living with them, 41.8% were married couples living together, 21.4% had a female householder with no husband present, and 33.2% were non-families. 30.6% of all households were made up of individuals and 14.9% had someone living alone who was 65 years of age or older. The average household size was 2.39 and the average family size was 3.00.
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